The Cyprus Protocol – Multimodal Combination Therapy for Long COVID, Post-Vac and Chronic Illnesses

In the field of HIV and cancer, combination therapy is one of the most successful forms of treatment – often it is the gold standard in the specific field. 

世界中の貢献者とともに、私たちの臨床経験と患者主導の研究を組み合わせることで、私たちは長期のCOVID、休暇後症候群、慢性疾患のための初の複合療法プロトコルを開発しました。

 We named it after it’s place of origin: 

キプロス議定書

Below you find a dynamic list of the protocol’s elements and a treatment schedule example.

私たちが治療する疾患

アフェレーシスセンターでは、キプロス・プロトコルでどのような症状を治療しますか?

以下は、当クリニックで扱う最も一般的な症状の例です(これらに限定されるものではありません):

  • ロング・コビット(PCS)
  • ポストバック(PVS)
  • 感染後/ウイルス感染後症候群
  • 体位性頻脈症候群
  • イーディーエス
  • MCAS / IBS / SIBO
  • パン/パンダ
  • PIMS / MIS-C
  • 自己免疫疾患
  • 慢性疲労症候群
  • 再活性化した症状(EBV、モノ、CMV、ヘルペス、バベシア、バルトネラ)
  • ライム病
  • 線維筋痛症
  • ME/CFS
  • 多発性硬化症
  • ループス
  • 関節リウマチ
  • シェーグレン症候群
  • Raynaud’s Disease
  • 強皮症
  • アルツハイマー
  • パーキンソン
  • SFN / ニューロパシー
  • メソ対流系
  • その他、炎症性、自己免疫性、微小循環の問題を伴う疾患、毒素や病原体を根源とする疾患。 

キプロス・プロトコルの要素

詳細については、キプロス・プロトコルの各要素をクリックしてください。

すべての患者に対して、プロトコルを個別に設定する必要がある。

With the new diagnostic tools of our D-T-R model – Continous Diagnostics we are now able to apply targeted treatments with higher precision. 

臨床栄養監督

Independent of the treatment a patient is undergoing – without adapted nutrition for the three treatment phases pre-treatment, on-treatment and post-treatment, the achievable results differ.
This is why we base our Combination Therapy on individual and personalized nutrition plans for every patient, based on the results of blood panel test and food intolerance test that show IgG reactions to 287 foods (vegetables, fish & seafood, fruits, spices, nuts, legumes, meat, egg & milk, cereals & seeds, nuts, coffee & tea and novel foods). 
Our Clinical Nutritionist Chryso Zorbas will hold your hand nutritionally from day one and guide you along the therapy with a personalized diet plan that will enhance your recovery process. Needless to say that our Health Coaching (see below) is a perfect match and goes hand in hand with our Clinical Nutrition Supervision.
Learn more about Clinical Nutrition Supervision here

ヘルス・コーチング

Chronic Illness is very complex – having an expert patient turned professional Health Coach by your side throughout your whole journey offers priceless knowlege and guidance.
Our Health Coach Tanja Walser will coach you from day one and guide you along the therapy with a personalized coaching plan that will include all the dos and don’ts and give you a headstart despite brainfog, anxiety or other symptoms you are battling with.
Learn more about Health Coaching here

H.E.L.P. アフェレーシス、イヌスフェレーシス®、免疫吸着法

Our most effective treatments to date: At the core of our multimodal Combination Therapy are several forms of Therapeutic Apheresis’ – special blood purifications by precipitation/adsorption/filtration procedures. They serve to treat microcirculation / blood flow issues (microclots are removed, blood flow increased) and removes pathogenic or disease-sustaining proteins as well as protein-bound substances and autoantibodies from the blood. Amongst other substances environmental toxins, inflammation proteins, viral spike protein, cholesterol + autoantibodies are removed

Learn more about H.E.L.P. Apheresis 
Learn more about Inuspheresis®  
Learn more about Immunoadsorption 
In some cases H.E.L.P. Apheresis will be combined with TPPE – Therapeutic Partial Plasma Exchange 

全身温熱療法

Heckel HT3000全身ハイパーサーミアシステムは、軽度から高熱まで、体の中心温度を目標温度まで上昇させることができます。全身ハイパーサーミアは、症状に対処するだけでなく、生体全体の調節制御の改善を再確立することも目的としています。ヘッケルの全身温熱療法システムは、健康増進から痛みの緩和、慢性疾患や癌の支持療法まで、幅広い病気や症状の治療に有意義に貢献します。ロングコヴィッドとポストヴァックでは、レセプターの遊離と病原性タンパク質の分解がさらに望まれる効果である。

IV Therapy – Intravenous Treatments (including Peptides and Chelation Agents)

Long Covid and many other Chronic Illnesses are at their root an endothelitis/vasculitis with severe inflammation, combined with hypercoagulation and often viral persistence. Autoimmunity components can be involved too. 
IV treatments work directly where needed the most: in the blood vessels in the desired concentration.

IV/Intravenous therapies that are used in our Long COVID and Chronic Illnesses Combination Therapy are:

– IV Vitamin C (Reducing inflammation)
– IV Glutathione (Antioxidant)
– IV Multivitamin Protocol (Balancing deficiencies)
– IV NAD+ (Metabolism/mitochondria benefits)
– IV Alpha Lipoic Acid (Metabolism/nerve pain reduction)
– IV Zinc (Reducing inflammation, speeding up recovery)
– IV Magnesium (Electrolyte reducing fatigue and anxiety)
– IV NAC (Reduces brainfog/relieves respiratory discomfort)
– IV Taurin (Is Cytoprotective (cell protective) and detoxyfying)
– IV Arginine (Increases elasticity of blood vessels and increases blood flow)
– IV Lysine (Increases cell healing and wound healing)
– Other IVs: Iron, Selenium, Amino Acids, Minerals and more

Peptide Therapy:

Peptide therapy offers a groundbreaking approach to restoring  balance and vitality for individuals struggling with long COVID,  post-vaccine syndrome, and chronic illnesses. Peptides are short chains  of amino acids that act as signaling molecules in the body, promoting  tissue repair, immune modulation, and cellular rejuvenation. By  targeting underlying dysfunctions such as inflammation, impaired  immunity, and mitochondrial damage, peptide therapy can accelerate  recovery, enhance energy, and support overall wellness. Tailored to each  patient’s unique needs, this therapy provides a safe and effective way  to improve quality of life, fostering the body’s natural ability to heal  and thrive.  

Find more information on our IV Therapy and Peptide Therapy click here for iv therapy and peptide therapy

Chelation Therapy:

Chelation therapy is a medical intervention characterized by the administration of chelating agents, substances with a high affinity for certain metal ions, to facilitate the removal of heavy metals and minerals from the body. 

Find more information on Chelation Therapy here

栄養補助食品療法

Our Nutraceutical treatment strategy for the detoxification from viral spike protein involves the following 4-step process:

The first step is preventing reinfection by blocking the receptors  on host cells, which the virus and viral spike protein use to gain  entry. 
The second step is to help restore autophagy processes, which are  the body’s natural way of cleaning out damaged cells and regenerating  new ones. 
The third step aids in liberating viruses and viral spike proteins by selectively targeting infected or transfected cells. 
The fourth step facilitates the sequestration of viral spike  protein and virus, effectively removing them. The most efficient way to  do this is H.E.L.P. Apheresis and where that is not possible, the use of  Algerol is indicated.

This  comprehensive approach aims to remove the spike protein from the body  safely while also enhancing the immune system’s ability to prevent  further infections.

At the end of our therapy course we add a 3-6 months NAC Augmented protocol.

Find more about Nutraceutical Therapy here

投薬プロトコル(抗ウイルス/抗凝固、その他)

Medication and supplement protocols increase H.E.L.P. Apheresis results further and can be used to treat patients symptom-specific. The protocols include Antiviral Protocols and Anticoagulation Protocols.

Symptoms the medication protocols focus on are:

– Viral persistence
– Persisting hyper coagulation
– MCAS (mastcell activation syndrome), often combined with gastroparesis
– Endothelial damage, often combined with hypercholesterolaemia 
– Neuro inflammation/brain inflammation
– Fatigue, PEM often combined with mitochondrial dysfunction
– Insomnia 
– Induced anxiety/paranoia/depression 
– Reactivated viruses
– Others

Find more information on Antiviral Therapy and Anticoagulation Therapy

痛みと不安の治療

Anxiety, Depression, PTSD, Chronic Pain and Fatigue Therapy for Long Covid and Chronic Illness
Are you or a loved one struggling with the lingering effects of Long Covid or battling the relentless challenges of chronic illness? At the Apheresis Center we understand the toll these conditions can take on both your physical and mental well-being. That’s why we offer revolutionary approaches to treatment.

Find more about Depression & Anxiety Therapy here

大腸水治療とMCAS治療

Colon Hydrotherapy, also known as colonic irrigation, constitutes an internal cleansing procedure designed to rid the colon of deleterious waste materials. This therapeutic intervention serves as a rapid and highly efficient means of detoxification for the body. The mild internal hydration expeditiously eliminates pathogenic toxins by leveraging the natural peristaltic movements, further facilitated by abdominal massage. Notably, this process has implications for individuals with symptoms that present similar to Mast Cell Activation Syndrome (MCAS), as it influence the systemic responses associated with this symptoms often triggered by Long Covid, Post Vac or other Chronic Illnesses.

Our Medical Team has designed a MCAS treatment package which is tailored to each patient individually

MCAS Blood Test (CCL2, IL-6, IL-8, IL-31, IL-33, TNF-alpha, Tryptase)
Nutrition Plan
3x Colon Hydrotherapy, ozonated treatment
3x Leaky Gut IV (L-Lysin, Taurin, L-Alanyl-Glutamin, Glycin, Cholinchlorid, Magnesiumchlorid, Kaliumchlorid 
MCAS Medication Plan including Nutraceuticals and Nanozeolites 

Find more information on Colon Hydrotherapy and MCAS Treatment here

IVIGとmABs療法

The application of Intravenous Immunoglobulin (IVIG, if subcutaneously administered also called SCIG)) and monoclonal antibodies (mABs) like Evusheld or Xevudy (Sotrovimab) represents a new area in treating Long Covid, Post Vac and Chronic Illnesses. These conditions involve complex immune dysregulation and inflammatory responses. IVIG is a concentrated preparation of immunoglobulins derived from pooled human plasma.
Monoclonal antibodies, designed to target specific components of the immune response, present another avenue for intervention. Both IVIG and mABs are being investigated for their potential to restore immune homeostasis.
The current official indications include symptoms present in chronic illness and many post-viral conditions: Myo- and Pericarditis, Small Fiber Neuropathy but also acute/severe conditions like Sepsis.

Find more about IVIG and mABs Therapy here

高気圧酸素 / クライオセラピー / オゾンEBOO

For specific symptoms and subgroups after H.E.L.P. Apheresis treatment these treatments can speed up and enforce the recovery process. (Note: HBOT is only administered after H.E.L.P. Apheresis therapy. Ozone-EBOO is only administered after H.E.L.P. Apheresis and only in special cases) 

Find more information on Hyperbaric Oxygen Treatment here and Cryotherapy here

ミトコンドリア療法

Mitochondrial therapy, also known as metabolic correction, is an emerging approach in the management of Long Covid and chronic illnesses characterized by fatigue. This therapy aims to enhance mitochondrial function, which is often impaired in these conditions, by providing specific nutrients and cofactors that support cellular energy production. Key substances used in mitochondrial therapy include NAC (N-Acetyl L-Cysteine), L-Serine, L-Carnitine, Nicotinamide Riboside (NR), L-Choline, NT Factor, and NADH. These compounds work synergistically to replenish depleted cellular antioxidants, enhance mitochondrial biogenesis, improve fatty acid metabolism, and restore ATP production, ultimately helping to alleviate fatigue and improve overall cellular health in individuals suffering from prolonged symptoms of Long Covid and other chronic fatigue-related conditions.

Find more about Mitochondrial Therapy here

‘Early Treatment Packages’ – Reinfection Care

Many of our last year’s patients had to come back to us for another course of H.E.L.P. Apheresis and Combination Therapy treatment, because they reinfected with Covid and were thrown back to experiencing Long Covid symptoms. This is why we started giving out ‘Early Treatment packages’ which avoid exactly that. Our prescribing doctors will supply you with everything needed to get through your next reinfection without risking to worsen again. 

治療スケジュール例

キプロス・プロトコルの治療オプションの視覚化

In the below PDF you find a visualisation of available treatments (this is solely for the purpose of demonstrating available options – this NOT a real life case/treatment schedule)

おすすめダウンロードし、拡大して詳細をご覧ください。

PDFダウンロード

長期休養/休暇後およびその他の症状に対する治療的アフェレーシスに関する科学的情報源と研究

H.E.L.P. アフェレーシス

A collection of sources which have published success rates can be found at the Long Covid Apheresis Community (LCA Community): https://lcacommunity.org/research

LCAコミュニティが発表した結果は、ISFA2023で確認されている:

ISFA 2023(国際アフェレシス学会世界会議)

Inuspheresis

Science 2024 – new study looking at the relation between microclots and immune damage in Long Covid:

Quote: ‘…coagulation in Long Covid is indicated by the detection of circulating fibrinolysis-resistant microclots that are enriched in vWF, C7, acute-phase serum amyloid proteins, and fibrin, proteins identified in the proteomics screen by Cervia-Hasler et al. as contributors to Long Covid.’

Full study: https://www.science.org/doi/10.1126/science.adn1077

簡単に言えば、この研究は、COVID-19(ロングコビドとして知られる状態)から回復した後も一部の人に症状が持続する理由を調査するものである。研究者らは、ロングコビド患者では免疫系、特に補体系の活性化が続いており、これが炎症や血栓形成につながっていることを発見した。肝臓が免疫反応に主要な役割を果たす急性COVID-19の時とは異なり、ロングCovidでは、炎症はより局所的で、組織や免疫細胞が関与しているようである。この研究は、特に補体系におけるこの持続的な免疫活性化が、ロングコビド患者が経験する症状の一因であることを示唆している。

研究者らは、ペントラキシン3や補体成分など、ロングコビドに関連する特定のタンパク質を特定した。補体系が制御されないと、細胞や血管に損傷を与える可能性がある。ロングコビド患者では、補体が過剰に活性化され、炎症とmicroclot 。血液凝固が広範囲に及んでいない場合でも、このような炎症状態が続いていることで、疲労や認知機能の問題など、ロングコビドで観察される長引く症状が説明できる。

さらに、血液凝固に関連する因子の不均衡も発見され、ロングコビドにおける血栓性炎症の潜在的なメカニズムが示唆された。ロングコビドにおける持続的な免疫活性化と血液凝固の正確な理由は完全には解明されていないが、この研究は、免疫系と血液凝固系の特定の構成要素を標的とすることが、ロングコビドにおける治療の可能性を示している。 

H.E.L.P. Apheresis and Inuspheresis®  address most if not all of the above. Microclots, Hypercoagulation, Inflammation, Pathogens to list just a few modes of action of H.E.L.P. Apheresis and Inuspheresis® . The rest can be addressed by other elements of the multimodal Combination Therapy of ‘The Cyprus Protocol’.

You will find extensive information on our blog post about different types of Apheresis and which type is suitable for which purpose HERE

当アフェレーシスセンターとH.E.L.P. アフェレーシスがテレビで紹介されました。

ITV News、BBC News、France 2、WDR TV。当アフェレシスセンターとH.E.L.P. アフェレシス(抗うつ剤投与後/長期休暇後症候群および慢性疾患)についての報道の一部抜粋。

お客様の声

ジェレミー・スミス(米国ロング・コビット

‘I had 4 Help Apheresis treatments last year in Germany. They brought me back to 80% of my former capacity. 

The Apheresis Center is a totally different experience and I am super happy I chose Cyprus. It is very different from Germany. The doctors, nurses and the whole team are doing everything to bring me back to my full capacity, their knowledge about Long Covid and the individually adapted treatment is great – a real concierge medicine experience! I missed home last year in Germany – here in Cyprus not a single day, we even extended our stay and will come back next year for holidays!’

You can read and watch Jeremy’s full story here: Full Video

カトリーナ・クルーラ(米国、ロング・コビッド

‘I have had some amazing results with H.E.L.P. Apheresis for my Long Covid – my 6th treatment got me back to feeling 75% to 90% recovered. Larnaca was truly an amazing place for recovery. Also the great community for support that formed with others getting treatment was so wonderful. It was so nice to have a team of people helping you that “got it” and believed you in addition to being with others suffering the same life changing illness.’

パトリシア・プライス、ME/CFS、英国

パトリシアは2015年から重度のMECFSに苦しんでいる:

‘My Help Apheresis treatment improved my ME by 80%. Help Apheresis took me from being mostly bed bound 23 hours a day – I could not be upright without my heart jumping to 170 beats per minute, even higher if I tried to have a shower – to being able to be upright and be mobile almost every day. It changed my life! I can now manage my own life again. I can go outside again and I was able to gain weight and can now eat three solid meals a day again!

You can watch Patricia’s full story here: Full Video

ランデン・ウィリアムズ(米ロング・コビド

ランデンは、H.E.L.P. アフェレーシスで治療する前は、呼吸、不安、脳霧、その他の症状で苦しんでいた。治療から数ヵ月後、ランデンは以前の70%まで回復し、疲労とPEMが最後の症状となっている。彼は併用療法でそれらに取り組んでいる。上のビデオは、1819ニュースに出演した際のショートバージョン/抜粋である(出典:1819news)。

Combination Therapy and H.E.L.P. Apheresis do not achieve the same results in the same time frame for different patients. From our clinical experience we have seen similar success rates as presented on the ISFA 2023 (World Conference of the International Society for Apheresis) – 80% success rate with results varying from smaller improvements to being fully curative. The majority of patients saw a significant improvement. Long Covid, Post Vac and CI are umbrella terms with different subsets – no patient presents the exact same symptoms set.

The time frame in which patients see results also vastly differs – from first treatment to several months. 

ARTE TVドキュメンタリー「ロング・コヴィッド-キプロスの癒し

ARTE TV Documentary ‘Long Covid – Healing in Cyprus’ about our Apheresis Center

The documentary aired in June 2024. A team of journalists from European TV channel ARTE TV accompanied three of our Long Covid and Post Vac Syndrom patients and interviewed them and our team at the Apheresis Center. Here you can watch an excerpt of the documentary which is also easy to watch for patients with cognitive dysfunction, brainfog and related migraines. English audio by Dubly.

Since the documentary was filmed, new scientific findings have been made, you can find the latest studies published here

Markus has published a blog post here, where he describes the developments and updates since the documentary was filmed.

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